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Clinical research is significant and should be considered a priority in the health sector as its findings to introduce safe and effective medicine into the health system.
With further clinical evaluation, the most effective and safest medicine are discovered and authorized for healthy administration.
The product was initially produced by chemist Dora Richardson in 1962. Tamoxifen also is known as Tamoxifen Citrate, or just TMX
Chemical and physical data Tamoxifen
Molecular formula: C26H29NO
Molecular mass: 371.515 g/mol
563.638 g/mol (citrate salt) g.mol-1
CAS number: 10540-29-1
Uses of Tamoxifen
Tamoxifen is one of the most effective compounds for the prevention of breast cancer and, it’s currently being investigated for other kinds of cancer. For effective prevention of breast cancer, it typically takes five years of oral consumption or any other effective means such as the use of injection in animals for research purposes.
Since its approval in 1998, the compound has been used for Albright Syndrome to treat premature puberty. It is popularly called McCune-Albright Syndrome (MAS). MAS is a disorder that affects the skin, bones, and endocrine or hormones-producing tissues.
Besides cancer and MAS treatments, Tamoxifen can be used for animal studies. It is administered into animals, the test subjects, as a research instrument to initiate tissue-specific gene expression in many conditional expression constructs of genetically modified animals.
Such administration into animals should be appropriately carried out in an LASC chemical housing room considering ABSL-2 type PPE (Personal Protective Equipment).
Administration of Tamoxifen in test subject (animals) can either be acute or chronic. Whatever the case may be, the use of an IP injection may be needed for a successful administration. The injection procedures for the administration should remain the same in both acute and chronic.
After successful administration, it is advisable for the test subject to be kept indoors in ABSL-2 for about three days.
Effects of Tamoxifen
Tamoxifen is one of the most used selective estrogen receptor modulator (SERM) or a partial agonist of the estrogen receptors (ER) and, it’s widely recommended for breast cancer and McCune-Albright Syndrome. There are several benefits that are derived from Tamoxifen.
Tamoxifen helps to:
- Reduce the risk of breast cancer
- Funk large hormone-receptor-positive before surgery
However, it will be a futile effort to use Tamoxifen for hormone-receptor-negative breast cancer as it only has used for hormone-receptor-positive breast cancer. As SERM, Tamoxifen has other benefits beyond using it for cancer and MAS treatment:
- Regulate cholesterol levels
- Stop the loss of bone (after menopause)
- Prevent osteoporosis
- Infertility treatment
Side effects of Tamoxifen
The following are possible side effects from tamoxifen:
- Possibility of weight gain but not in all cases
- The pressure at the pelvic area
- Tenderness or numbness of the leg
- Chest pain
- Shortness of breath when talking
- Difficulty in speaking fluently
- Severe headaches or migraine
- Dizziness and problem with sight
Mechanism of action
The mechanism of action Tamoxifen or Tamoxifen/TMX is complex. It has been successful in rats. Furthermore, animal studies/research carried out using rats with the use of nitrosomethylurea and dimethylbenzanthracene (DMBA) as carcinogens revealed Tamoxifen was tremendously effective for the prevention of the development of experimental breast cancer.
Tamoxifen can be purchased in research form from Loti Labs. Tamoxifen generally is sold in liquid form in a concentration of 20mg per ml. Be sure that when purchasing tamoxifen you do so from a reputable online vendor that uses 3rd party testing on their products.
- Tamoxifen Citrate. NCI. August 26, 2015. Archived from the original on 4 January 2016.Retrieved 28 November 2015.
- Selective estrogen receptor modulators. Archived from the original on the 9 December 2013. I have retrieved 28 November 2015.
- Jordan VC (January 2006). Tamoxifen (ICI46,474) as a therapy which was produced to treat and prevent breast cancer. British Journal of Pharmacology. 147 Suppl 1 (Suppl 1): S269-76.